The Anti-ABRA1 Purified Antibody from MyBioSource.com is a Mouse Monoclonal antibody to ABRAXAS1. This antibody recognizes Human antigen. The Anti-ABRA1 Purified Antibody has been validated for the following applications: Flow Cytometry, Immunoprecipitation, and Western Blot.
Description
ABRA1 (Abraxas), also known as CCDC98, is an adaptor protein that is essential for formation and function of BRCA1 A tumor suppressor complex. This complex plays critical roles in DNA repair, cell cycle checkpoint control, and maintenance of genomic stability. ABRA1 mediates interaction of ubiquitin-interacting motif-containing protein RAP80 and deubiquitination enzyme BRCC36 with BRCA1/BARD1. ABRA1 controls both DNA-damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation